Formulation and optimization of Aceclofenac gel

Abstract

The present research work is to formulate and optimize Aceclofenac gel. Fourier Transfer Infrared Spectroscopy (FT-IR) study revealed no chemical interaction between drug and polymers. The formulations were prepared by using various polymers like Carbopol 934 and HPMC K15M. The formulated gels were evaluated for several physicochemical parameters like drug-polymer interaction, pH, Viscosity, Spredability, Drug content uniformity, In vitro drug release. The formulation F9 Showed maximum drug diffusion rate. The optimization study was carried out to find out effect of two independent variable on diffusion rate at 3 hour and diffusion rate at 6 hour. Optimization was performed by the help of software DESIGN EXPERT 8.0.6 trial. From this study, it was find out that as the concentration of polymer increases, the drug release will decreases.