Effects of medium and culture conditions on folate production by Streptococcus thermophilus BAA-250

Authors

  • Seyed Sadegh Mousavi Universiti Putra Malaysia
  • Hassan Moeini Universiti Putra Malaysia
  • Rosfarizan Mohamad
  • Mojdeh Dinarvand
  • Arbakariya Ariff
  • Foo Hooi Ling
  • Abdul Rahim Raha

Keywords:

Folate, lactic acid bacteria, kinetic model, Streptococcus thermophilus

Abstract

The present study was conducted to investigate the effects of culture conditions on folate production by Streptococcus thermophilus BAA-250. Lactose (3g/L) and yeast extract (20g/L) were found to be the more suitable carbon and nitrogen sources for folate production by S. thermophilus BAA-250. para-aminobenzoic acid (pABA) higher than 1 µM had no significant effect on folate biosynthesis. The optimum pH for folate production was shown to be 7.0 with a folate yield and productivity of 54.53 (µg/L) and 2.27 (µg/L.h), respectively. Optimum folate production obtained in the presence of lactose and yeast extract in a controlled pH of 7 during batch fermentation in bioreactor. Kinetic studies indicated that folate production by S. thermophilus is growth-associated process.

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Published

19-11-2013

How to Cite

Mousavi, S. S., Moeini, H., Mohamad, R., Dinarvand, M., Ariff, A., Ling, F. H., & Raha, A. R. (2013). Effects of medium and culture conditions on folate production by Streptococcus thermophilus BAA-250. Research in Biotechnology, 4(6). Retrieved from https://www.updatepublishing.com/journal/index.php/rib/article/view/2446

Issue

Vol. 4 No. 6 (2013)

Section

Research Articles