Effect of differential oral dose administration of aqueous leaf extract of Senna occidentalis, Annona muricata and Aju Mbaise on serum electrolyte levels in Albino rats

Authors

  • Esther Ifeyinwa Etu Department of Anatomic Pathology, Alex Ekwueme Federal University, Ndufu Alike, Ebonyi State, Nigeria
  • Chiagozie Chinyere Umeano Department of Medical Laboratory Science, Faculty of Health Science and Technology, University of Nigeria, Enugu Campus, Nigeria
  • Nyejirime Young Wike Department of Human Physiology, State University of Medical and Applied Science, Igbo-eno, Enugu State, Nigeria
  • O. Odeh Chibueze Department of Biochemistry, University of Calabar, Nigeria
  • Ndubuisi Nonso Richards Department of Science Laboratory Technology, University of Nigeria, Nsukka, Nigeria
  • Kenneth Eze Etu Department of Pharmacology, Faculty of Basic Clinical Sciences, Ebonyi State University, Abakiliki, Nigeria
  • Uche Bethel Mmesomachi Department of Medical Laboratory Science, Faculty of Health Sciences, Ebonyi State University, Abakiliki, Nigeria
  • Chinedu Pascal Maduka Department of Medical Laboratory Science, Faculty of Health Science and Technology, University of Nigeria, Enugu Campus, Nigeria
  • Ekoh Adaorah Jennifer Department of Medical Laboratory Science, Enugu State College of Medicine, Parklane, Enugu, Nigeria
  • Chukwu Chigozie David Department of Medical Laboratory Science, David Umahi Federal University of Medical Sciences, Uburu, Ebonyi State, Nigeria
  • Gabriel Silas Chinedu Department of Medical Laboratory Science, Evangel University, Akaeze, Ebonyi State, Nigeria
  • Chiamaka Esochaghi Department of Medical Laboratory Science, Evangel University, Akaeze, Ebonyi State, Nigeria
  • Eteng Komomor Willie Department of Medical Laboratory Science, Evangel University, Akaeze, Ebonyi State, Nigeria
  • Achi Franklyn Ugochukwu Department of Medical Laboratory Science, Faculty of Health Science and Technology, University of Nigeria, Enugu Campus, Nigeria
  • Maria Chinedu Department of Histopathology, Enugu State University of Science and Technology, Nigeria
  • Ezeobiora John Ozioma Department of Medical Laboratory Science, Faculty of Health Science and Technology, University of Nigeria, Enugu Campus, Nigeria

DOI:

https://doi.org/10.25081/jmhe.2024.v10.9019

Keywords:

Electrolyte, Potassium, Chloride, Bicarbonate, Sodium

Abstract

Electrolyte imbalances are frequent in medical practice, mostly seen in hospital populations, affecting a wide range of patients and linked to higher rates of morbidity and death. Herbal medicine has been the most accessible and economical form of treatment and it has demonstrated significant promise for the management of a variety of health issues. This study evaluated the effect of differential oral dose administration of aqueous leaf extract of Senna occidentalis, Annona muricata and Aju Mbaise on serum electrolyte levels in albino rats. Twenty Albino rats were used for this study. The rats were grouped into four with 4 rats each. Oral administration of S. occidentalis, A. muricata and Aju Mbaise were carried out at different doses (200, 400 and 500 mg kg-1 respectively) for 4 weeks. The rats were sacrificed by jugular decapitation 24 hours after the last administration of the extract and blood samples were collected for serum electrolyte analysis. The result revealed a significant increase p<0.05 for chloride, bicarbonate, sodium and potassium ions for the leaf extracts of S. occidentalis, A. muricata and Aju Mbaise. This implies that the leaves of these plants can be toxic and it is therefore advised that consumption of these leaves should be at therapeutic doses since it is associated with an increase in electrolyte levels.

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Published

22-10-2024

How to Cite

Etu, E. I., Umeano, C. C., Wike, N. Y., Chibueze, O. O., Richards, N. N., Etu, K. E., Mmesomachi, U. B., Maduka, C. P., Jennifer, E. A., David, C. C., Chinedu, G. S., Esochaghi, C., Willie, E. K., Ugochukwu, A. F., Chinedu, M., & Ozioma, E. J. (2024). Effect of differential oral dose administration of aqueous leaf extract of Senna occidentalis, Annona muricata and Aju Mbaise on serum electrolyte levels in Albino rats. Journal of Medicinal Herbs and Ethnomedicine, 10, 48–51. https://doi.org/10.25081/jmhe.2024.v10.9019

Issue

Volume 10, 2024

Section

Articles

Copyright (c) 2024 Esther Ifeyinwa Etu, Chiagozie Chinyere Umeano, Nyejirime Young Wike, O. Odeh Chibueze, Ndubuisi Nonso Richards, Kenneth Eze Etu, Uche Bethel Mmesomachi, Chinedu Pascal Maduka, Ekoh Adaorah Jennifer, Chukwu Chigozie David, Gabriel Silas Chinedu, Chiamaka Esochaghi, Eteng Komomor Willie, Achi Franklyn Ugochukwu, Maria Chinedu, Ezeobiora John Ozioma

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This work is licensed under a Creative Commons Attribution 4.0 International License.