Synthesis and antibacterial activity of some new schiff bases and 2-Azetidinones containing iodohyydroxy biphenyl moiety

Authors

  • Subhash B Junne Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.
  • Archana B Kadam Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.
  • Sainath B Zangade Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.
  • Saheb L Shinde Department of Botany, Yeshwant Mahavidyalaya, Nanded (MS.) India.
  • Yeshwant B Vibhute Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Keywords:

2-Hydroxy-3-iodo-5-phenylbenzaldehyde, Schiff bases, 2-azetidinones, antibacterial activity.

Abstract

2-Hydroxy-5-phenylbenzaldehyde on iodination yielded 2-Hydroxy-3-iodo-5-phenylbenzaldehyde. This aldehyde on facile condensation with substituted aromatic amines in presence of catalytic amount of acetic acid to afford new series of Schiff bases. Further these Schiff bases on cyclocondensation reaction with chloroacetyl chloride afforded a biologically active 2-azetidinones derivatives. The structure of newly synthesized compounds characterized on the basis of elemental analysis and spectral data. The compounds prepared were tested against Xanthomonas citri, Escherichia coli, Erwinia carotovora and Bacillus subtilis. Some of these compounds showed potential antibacterial activity.

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Author Biographies

Subhash B Junne, Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Archana B Kadam, Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Sainath B Zangade, Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Saheb L Shinde, Department of Botany, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Department of Botany, Yeshwant Mahavidyalaya, Nanded (MS.) India..

Yeshwant B Vibhute, Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Organic Synthesis Laboratory, P. G. Department of studies in Chemistry, Yeshwant Mahavidyalaya, Nanded (MS.) India.

Published

08-06-2012

How to Cite

Junne, S. B., A. B. Kadam, S. B. Zangade, S. L. Shinde, and Y. B. Vibhute. “Synthesis and Antibacterial Activity of Some New Schiff Bases and 2-Azetidinones Containing Iodohyydroxy Biphenyl Moiety”. International Multidisciplinary Research Journal, vol. 2, no. 6, June 2012, https://www.updatepublishing.com/journal/index.php/imrj/article/view/1615.

Issue

Vol. 2 No. 6 (2012)

Section

Research Articles