https://www.updatepublishing.com/journal/index.php/ripb en-US [email protected] (Managing Editor) [email protected] (Managing Editor) Mon, 08 Jan 2024 12:53:57 +0530 OJS 3.3.0.8 http://blogs.law.harvard.edu/tech/rss 60 https://www.updatepublishing.com/journal/index.php/ripb/article/view/9207 <p>Diabetes mellitus (DM) is a major worldwide health burden that requires research into cost-effective treatment alternatives. It has been claimed that herbal medicines, have improved glucose metabolism in diabetics. It has been showed that several plant extracts are useful in preserving glucose homeostasis. Therefore, the present study aimed to evaluate the phytochemical and antidiabetic activities of <em>Bombax buonopozense </em>methanol leaf extracts. Standard methods were used for the identification of alkaloids, tannins, flavonoids, saponins, phenolics, cardiacglycosides and steroids. The enzyme inhibitory activities of the extracts of <em>B. buonopozense </em>was evaluated on α-amylase and α-glucosidase. The crude leaf extract of <em>B. buonopozense </em>exhibited a more effective inhibition on α-glucosidase with IC₅₀ (Half maximal inhibitory concentration) values 888.20±35.06 μg/mL when compared to control (ascorbic acid) with values 1076±2.77 μg/mL. Fractions of ethyl acetate showed lower inhibitory property of alpha glucosidase with IC₅₀ value 18.44±2.63 μg/mL compared to the control (ascorbic acid with IC₅₀ value 16325±1318 μg/mL). This study showed the scientific basis for the traditional therapeutic usage of <em>B. buonopozense </em>by proven its antidiabetic activity in vitro. This is the first time that <em>B. buonopozense</em>’s antidiabetic efficacy and possible mechanisms have been documented.</p> Samira A. Abdullahi, Salisu Abubakar Maiwada, Aminu Ibrahim Copyright (c) 2024 Samira A. Abdullahi, Salisu Abubakar Maiwada, Aminu Ibrahim http://creativecommons.org/licenses/by-nc-nd/4.0 https://www.updatepublishing.com/journal/index.php/ripb/article/view/9207 Mon, 02 Dec 2024 00:00:00 +0530