https://www.updatepublishing.com/journal/index.php/ripb/issue/feed 2024-10-02T18:38:33+0530 Managing Editor [email protected] Open Journal Systems https://www.updatepublishing.com/journal/index.php/ripb/article/view/9207 2024-10-02T18:38:33+0530 Samira A. Abdullahi [email protected] Salisu Abubakar Maiwada [email protected] Aminu Ibrahim [email protected]

<p>Diabetes mellitus (DM) is a major worldwide health burden that requires research into cost-effective treatment alternatives. It has been claimed that herbal medicines, have improved glucose metabolism in diabetics. It has been showed that several plant extracts are useful in preserving glucose homeostasis. Therefore, the present study aimed to evaluate the phytochemical and antidiabetic activities of <em>Bombax buonopozense </em>methanol leaf extracts. Standard methods were used for the identification of alkaloids, tannins, flavonoids, saponins, phenolics, cardiacglycosides and steroids. The enzyme inhibitory activities of the extracts of <em>B. buonopozense </em>was evaluated on α-amylase and α-glucosidase. The crude leaf extract of <em>B. buonopozense </em>exhibited a more effective inhibition on α-glucosidase with IC₅₀ (Half maximal inhibitory concentration) values 888.20±35.06 μg/mL when compared to control (ascorbic acid) with values 1076±2.77 μg/mL. Fractions of ethyl acetate showed lower inhibitory property of alpha glucosidase with IC₅₀ value 18.44±2.63 μg/mL compared to the control (ascorbic acid with IC₅₀ value 16325±1318 μg/mL). This study showed the scientific basis for the traditional therapeutic usage of <em>B. buonopozense </em>by proven its antidiabetic activity in vitro. This is the first time that <em>B. buonopozense</em>’s antidiabetic efficacy and possible mechanisms have been documented.</p>

2024-12-02T00:00:00+0530 Copyright (c) 2024 Samira A. Abdullahi, Salisu Abubakar Maiwada, Aminu Ibrahim