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TY - JOUR AU - Kini, Deepthi. D. AU - Mathew, Jessy Elizabeth PY - 2015/12/28 Y2 - 2025/09/23 TI - Novel 3-(substitutedbenzylideneamino)-5-methyl-1H-pyrazol-1-yl)(phenyl)methanone Derivatives Against Gram-positive, Gram-negative and fungal pathogenic strains JF - Research in Pharmacy JA - RIP VL - 5 IS - 0 SE - Articles DO - UR - https://www.updatepublishing.com/journal/index.php/rip/article/view/2933 SP - AB - <p><strong>          A series of novel</strong><strong>3-(substitutedbenzylideneamino)-5-methyl-1H-pyrazol-1-yl)(phenyl) methanone P1-12 derivatives were synthesized. The chemical structures of the compounds were proved by means of their IR, ¹H-NMR, mass spectroscopic data and elemental analyses. The results showed that most of the synthesized compounds exhibited significant anti-bacterial and anti-fungal activities. Among the synthesized compounds P2, P5, P8, and P9 exhibited most potent <em>in vitro</em> antimicrobial activity. On the basis of the microbial results, further  insight  into  the  structural  requirements  for  targeting  pyrazol-1-yl)(phenyl) methanone to develop potential new agents to combat treatment of </strong><strong>pathogenic strains</strong><strong>.</strong></p> ER -