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TY - JOUR AU - Azharuddin, Mohd AU - Kamath, Krishnananda AU - Panneerselvam, T. AU - S. Pillai, Subash AU - Shabaraya, A.R. PY - 2011/09/23 Y2 - 2025/09/23 TI - Formulation and evaluation of controlled release matrix tablets of antihypertensive drug using natural and synthetic hydrophilic polymers JF - Research in Biotechnology JA - RIB VL - 2 IS - 4 SE - Research Articles DO - UR - https://www.updatepublishing.com/journal/index.php/rib/article/view/2366 SP - AB - The present study is to prepare and evaluate controlled release matrix tablets of Losartan potassium using natural and synthetic polymers. Tablets were prepared by direct compression method using different drug: polymer concentration. Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) study revealed no chemical interaction between drug and polymers used. Precompression and postcompression parameters complied with pharmacopoeial limit for the tablets. <em>In-vitro</em> release studies was performed and the results indicates that matrix tablet  (F9) containing 50% w/w blend of natural and synthetic polymer has better controlled release for a period of 24 h. ER -