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@article{Raja2, T.S. Mahendran1, J. Muthumary2, P.T. Kalaichelvan2, K. Murugesan2_2011, title={Antimutagenicity of mangiferin purified from Salacia chinensis Linn.}, volume={1}, url={https://www.updatepublishing.com/journal/index.php/imrj/article/view/1460}, abstractNote={<div style="border-right: medium none; padding-right: 0in; border-top: windowtext 1pt solid; padding-left: 0in; padding-bottom: 0in; margin-left: 34pt; border-left: medium none; margin-right: 34pt; padding-top: 1pt; border-bottom: medium none; mso-element: para-border-div; mso-border-top-alt: solid windowtext .5pt;"><p class="3Abstract" style="margin: 12pt 0in 0pt; mso-border-top-alt: solid windowtext .5pt; mso-padding-alt: 1.0pt 0in 0in 0in; padding: 0in;"><span style="font-size: x-small;"><span style="font-family: Times New Roman;">Mangiferin is a xanthone glucoside and an active phytochemical present in common principal constituent of <em>Salacia</em> species. Mangiferin was purified from methanolic root extract of <em>Salacia chinensis</em>. Mangiferin is recommended to treat immuno-deficiency diseases such as diabetes, hepatitis, arthritis, cardiac and mental disorders. Mangiferin was evaluated for antimutagenicity studies in order to confirm the safety of its usage. </span></span></p><p class="3Abstract" style="margin: 0in 0in 0pt; mso-border-top-alt: solid windowtext .5pt; mso-padding-alt: 1.0pt 0in 0in 0in; padding: 0in;"><span style="font-size: x-small;"><span style="font-family: Times New Roman;">Mangiferin showed no mutagenicity up to 5 mg/plate when tested with <em>Salmonella typhimurium</em> TA97a, TA98, TA100, TA102 and TA1535 strains with or without metabolic activation. On the other hand mangiferin showed a significant protective effect against mutagenicity induced by mutagen in <em>S. typhimurium</em> TA98 and TA100 strain with or without metabolic activation. The results of these studies indicate that mangiferin is non-mutagenic in Ames test, exhibit protection against the mutagenicity induced by 4-nitroquinolene-1-oxide, sodium azide and 2-aminoflourene in TA98 and TA100 strain.</span></span></p></div>}, number={1}, journal={International Multidisciplinary Research Journal}, author={Raja2, T.S. Mahendran1, J. Muthumary2, P.T. Kalaichelvan2, K. Murugesan2, S. Periyar Selvam1*, V. Magesh3, V.}, year={2011}, month={May} }